Study: ginger and multiple sclerosis

Reference

Foshati s, poursadeghfard M, Heidari Z, Amani R. The effect of ginger ( zingiber officinale ) Supplement to clinical, biochemical and anthropometric parameters in patients with multiple sclerosis: a double -blind, randomized, controlled study. food function. 2023; 14 (8): 3701-3711.

Study goal

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to determine whether a ginger supplement affects the symptoms of multiple sclerosis (MS) over a period of 12 weeks

Key to take away

After 12 weeks, the treatment with ginger objectively and subjectively significantly improved the MS disability, but had no significant influence on the body mass index (BMI).

Design

randomized, placebo -controlled double -blind study

participant

The final analysis comprised 52 subjects (at the age of 18–50 years) with a push -in -cheek -shaped multiple sclerosis (RRMS). The investigators examined 196 adults; 135 did not meet the criteria and 9 rejected participation. This left 52 participants: 26 in the treatment group and 26 in the placebo group. A participant from the treatment group and two from the placebo group were suffering from SARS-COV-2 during the follow-up examination in week 12, but the researchers included all 52 in the intention-to-treat analysis.

inclusion criteria: men and non-menopausal women between the ages of 18 and 50, score of < 4.5 on the Expanded Disability Status Scale (EDSS), no MS relapse or corticosteroid therapy in the past 3 months, no change in the type or dose of MS medication in the past 6 months and willingness Participation.

exclusion criteria: other autoimmune diseases, cancer, pregnancy, MS relapse or corticosteroid therapy during the study, change in the dose or type of MS medication during the study, allergic reaction to ginger or placebo (corn), supplement with antioxidants or nutrients except vitamin D, or less than 90 % Ginger or placebo supplements.

Intervention

The participants took 1 capsule 1 capsule either ginger (500 mg per capsule) or corn (500 mg per capsule), prepared by Dineh Iran Industries complex, Tehran, Iran, one.

Each 500 mg vesselapsel contained 25 mg gingerole, which corresponds to a total dose of 75 mg of gingeroles per day. Each bottle of placeboapsules was added to a small amount of ginger powder to create a similar ginger smell. The participants took ginger or placebo for breakfast for 12 weeks, lunch and dinner, a total of 1,500 mg per day.

studied study parameters

Extended Disability Status Scale (EDSS), Multiple Sclerosis Impact Scale (MSIS-29), BMI, Neurofilament light chain (NFL), neutrophil-lymphocyte ratio (NLR), interleukin 17 (IL-17) and matrix metalloproteinase-9 (MMP-9).

most important findings

Treatment with 500 mg ginger three times a day, with a daily total absorption of 75 mg Gingerolen, led to a significant improvement in the MS disability (EDSS), the physical MSIS-29 and psychological MSI 29 scores; It also significantly reduced NLR and IL-17, but had no significant influence on MMP-9 or BMI.

The MSIS-29-physics scale differed significantly, with a higher value in the ginger group, which indicates a higher degree of physical disability in the treatment group. The food intake of macro and micronutrients as well as the energy consumption did not differ significantly between the ginger and placebo group during the experiment.

After a 12-week ginger supplementation of 1,500 mg/day, the EDSS, MSIS-29-physics and MSIS-29-psycho-scores and IL-17 had decreased significantly. In the placebo group, EDSS, MSIS-29 physically and MSIS-29 psychologically, IL-17, NFL and NLR rose significantly.

In none of the groups there was a significant change in the BMI or MMP-9. In the ginger group, the researchers found no significant change in NFL or NLR. The authors argue that these changes were statistically and clinically significant changes in an MS patient, which could also be the case, but there were no physical tests or studies to confirm or refute these results, but only the views of the patients who were obtained from a questionnaire after 12 weeks.

Side effects were reported in 2 treatment patients and 3 control patients. They included heartburn and abdominal pain in the treatment group and in the control group heartburn with two and headache in one person. If we take into account the nature of this plant substance, the side effects in the treatment group are not unexpected, especially if the participants did not adhere to instructions for taking together with a meal. The researchers did not report any subjects who had taken less than 90 % of the capsules required during the test.

Transparency

The authors of the study stated that there are no conflicts of interest. The study was financed by the Isfahan University of Medical Sciences under the support number 3400357.

Effects and restrictions for practice

Zingiber Officinal is a well-known anti-inflammatory plant and food remedies that contain gingerol, shogaye, zingeron, quercetin, alpha curcumen and other active components. pointed out. 2.3 A mouse study showed that gingerol-6 inhibited migration of inflammatory cells from the peripheral nervous system to the central nervous system to the central nervous system, neuroinflammation and demyelinization, the activation of dendritic cells by lipopolysaccharides and the phosphorylation of NF-IB (nuclear factor Kappa light chain) inhibited-amplifier activated B cells), all of which could be factors at MS.

clinically it has positive effects on bacterial infections, colic, atonic dyspepsia, stomach acid, headache, rheumatism, inflammation and diabetes.

A current process against zingiber and Pilates ran for 12 weeks. At the end of the 12 weeks, the ginger plus pilades arm had a significant increase in the neurotrophic factor (BDNF) derived from the brain and a significant decrease in the tumor necrosis factor alpha, compared to the Pilates arms only, only ginger and the control arms.

Zingiber is located in East and Southeast Asia. The Romans brought it to Europe from Arabic traders and it became popular in the 9th century th . The Spaniard Francesco de Mendoza later brought it to Mexico. ^{6 The cultivation of ginger has been operated in India for more than 3,000 years. 6 Within this genre, there are several types, and the common name ginger comprises several species in the genus alpinia , asarum , and kaempferia . 6 Today it is mainly grown in Nigeria (56.2 %), India (23.6 %) and China (4.5 %). Dyspepsia, stomach acid, headache, rheumatism, inflammation and diabetes. 6 It also has antioxidant properties when cooking and roasting. Zingiber Officinal .}

Summary

In this process Zingiber official at 500 mg three times a day compared to a placebo made of corn with a similar smell had a positive effect on the multiple-sclerosis disabilities (EDSS) and the physical and psychological MSIS-29 scores, together with a reduction of IL-17 and NLR, But had no impact on the BMI or MMP-9. The dose of 1,500 mg was within the generally recognized safe dose of 4,000 mg per day. In this study, physical examinations or similar assessments of clinical effectiveness were missing. The side effects were minimal and included heartburn and abdominal pain. This could be an effective treatment for MS patients in the long term if researchers can demonstrate the neurological knowledge from animal experiments on humans.

The study was easy to read and follow, but the researchers did not describe the exact treatment method, such as Zingiber Officinal preparation and standardization, which will make replication or parallel studies a challenge.