Study: Following status in early pregnancy and hyperactivity in childhood

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In dieser Studie wird der Zusammenhang zwischen dem Folatstatus der Mütter während der Schwangerschaft und dem Verhalten ihrer Kinder untersucht. Es wurde festgestellt, dass ein niedriger Folatstatus in den roten Blutkörperchen der Mütter mit Hyperaktivität und Problemen mit Gleichaltrigen bei den Kindern zusammenhängt. Die Studie betont auch, dass ein niedriger Folatstatus mit einem verminderten Gehirnwachstum des Fötus in Verbindung gebracht wird. Es wird darauf hingewiesen, dass die Ernährung der Mutter während der Schwangerschaft eine wichtige Rolle spielt, insbesondere im ersten Trimester. Eine ausreichende Folataufnahme wird als wichtig erachtet, da ein Mangel negative Auswirkungen auf die neurologische Entwicklung des Fötus haben …
In this study, the connection between the folding status of mothers is examined during pregnancy and the behavior of their children. It was found that low folding status in the red blood cells of mothers are related to hyperactivity and problems with the children of peers. The study also emphasizes that low folding status is associated with a reduced brain growth of the fetus. It is pointed out that the mother's nutrition plays an important role during pregnancy, especially in the first trimester. Sufficient folate intake is considered important because a deficiency have negative effects on the neurological development of the fetus ... (Symbolbild/natur.wiki)

In this study, the connection between the folding status of mothers is examined during pregnancy and the behavior of their children. It was found that low folding status in the red blood cells of mothers are related to hyperactivity and problems with the children of peers. The study also emphasizes that low folding status is associated with a reduced brain growth of the fetus. It is pointed out that the mother's nutrition plays an important role during pregnancy, especially in the first trimester. Sufficient folate intake is considered important because a deficiency can have negative effects on the neurological development of the fetus.

Reference

Schlotz W, Jones A, Phillips di, Gale CR, Robinson SM, Godfrey KM. A low folding status of the mother in early pregnancy is associated with hyperactivity in childhood and problems with peers in the descendants. j child psychiatry . 2010; 51 (5): 594-602.

Design

prospective cohort study

participant

The authors tested 100 mothers on the folding level of the red blood cells at the end of the first trimester and the recording was assessed during the entire pregnancy of the participants. The newborn's head circumference was measured and the weight was measured at the birth and at the age of 9 months. When the children were 8.7 years old, the mothers were asked to fill a questionnaire to the behavior of their children, which included hyperactivity, emotional symptoms, behavioral problems and problems with the same age. The authors controlled the mother's smoking, alcohol consumption and gender.

most important knowledge

The mothers of these children, of whom they later reported that they had a high degree of hyperactivity and problems with peers, it was found that both the folding level in the red blood cells and the overall seizure were lower. The span of the folate recording for mothers was 328.5–624.4 µg in early pregnancy and in late pregnancy at 269.9–410 µg. Control of smoking and alcohol consumption of mothers during pregnancy did not change the results.

effects on practice

This study is the first to show a connection between the folding status of the mothers and the behavioral results of their children. In addition, they found that a reduced head growth speed was also associated with a lower folding level during pregnancy. It should be noted that head growth is a gross indicator of brain growth.

However, there was a connection here that indicates that the folding status in the uterus influences neurological development and that reduced fetal brain growth is one of the results.

However, there was a connection here that indicates that the folding status in the uterus influences neurological development and that reduced fetal brain growth is one of the results. It is known that an inadequate prenatal folka recording affects other aspects of the development of the nervous system, which is documented by the connection with spina bifida and other vertebral icing sulesraphisms. This study also provides information about when the folding status could be more important. In this case, the evidence indicates the first trimester. In fact, other studies have shown that nutritional status in early pregnancy has a greater influence than later during pregnancy. It is worrying that nutrition could play such an important role in the growing fetus, and at a time when many mothers may not even know that they are pregnant, or believe that prenatal nutrition is not particularly important. It is even more worrying that the mothers' folate recording in this study deviated far from the recommended prenatal minimum dose of 400 µg. It is possible that other disruptive factors influence the folding status and the usable folate, such as: B. tobacco smoke, oral contraceptives, trimethoprim, methotrexate or sulfasalazine. Therefore, taking these substances by mothers before pregnancy can bring a further disadvantage compared to other women who do not take these substances.

It is known that the folate deficiency reduces the cell replication of the fetus. 2 Especially in the brain, 3.4 which leads to a smaller brain size 5 and behavioral problems. 6 Dopaminergic systems influenced the risk of later hyperactivity. Other research results create a rather clear connection between the folate and the Attention deficit hyperactivity Disorder (ADHD). Survivors of pediatric leukemia, which have mutations in the 5.10-methylentetrahydroreductase (MTHFR), a crucial enzyme that provides usable foil for DNA synthesis later show adhs symptoms. be used, to be impaired.

The authors themselves state that there are many disruptive factors, especially after the child was born. However, if you look at the previous literature, it makes sense that the behavior is influenced. This may not be the only factor, but it is certainly an important factor that should be taken into account when advising mothers in their family planning. This could be even more important for mothers who suffer from an attention deficit disorder (ADS), ADHD or depression. In addition, it is important to note that mothers who have given birth to a child with a neural tube defect in the past have a significantly increased risk of neural tube defects in subsequent births. Therefore, these mothers need a much higher fake schedule from one month before pregnancy, up to 4 mg.