Study: Effective, natural treatment for Gerd: Aloe Vera Sirup

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Cover Panahi Y, Khedmat H, Valizadegan G, Mohtashami R, Saebkar A. Effectiveness and security of aloe vera syrup for the treatment of gastroesophageal reflux disease: a randomized, positively controlled pilot study. J. Tradit Chin Med. 2015; 35 (6): 632-636. Study target to evaluate the effectiveness of aloe vera in reducing the symptoms of gastroesophageal reflux disease (Gerd) and with the effectiveness of omeprazole, a proton pump inhibitor (ppi), and ranitidine, a histamine-2 receptor antagonist (H2RA) designed, open, positively controlled study dose received either 10 ml aloe vera syrup per day (standardized on 5.0 mg polysaccharide per ml), an omeprazole capsule (20 mg per day) or ranitidine tablets (150 mg in the morning and 150 ...
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reference

Panahi Y, Khedmat H, Valizadegan G, Mohtashami R, Saebkar A. Effectiveness and safety of Aloe Vera syrup for the treatment of gastroesophageal reflux disease: a randomized, positively controlled pilot study. j. Tradit Chin Med . 2015; 35 (6): 632-636.

Study goal

to evaluate the effectiveness of aloe vera when reducing the symptoms of gastroesophageal reflux disease (Gerd) and with the effectiveness of omeprazole, a proton pump inhibitor (PPI), and ranitidine, a histamine-2 receptor antagonist (H 2

Design

randomized, open, positively controlled study

dosage

The participants received either 10 ml aloe vera syrup per day (standardized on 5.0 mg polysaccharide per ml), an omeprazole capsule (20 mg per day) or ranitidine tablets (150 mg in the morning and 150 mg in the evening before going to bed) for a period of 4 weeks.

participant

The participants were between 18 and 65 years old, had the diagnosis Gerd and were transferred to endoscopy. A total of 79 participants were included in the study; However, 4 participants left due to side effects (2 in the Ranitidin Group and 2 in the Omeprazole Group). The exclusion criteria included pregnancy, breastfeeding and presence of hematemesis, odynophagia, treatment-resistant Gerd, other gastrointestinal diseases, liver diseases, hematological diseases, use of muscle relaxation or history of sensitivity to aloe vera.

study parameters and primary results

A modified questionnaire on reflux disease, consisting of 8 key symptoms of Gerd (heartburn, belching, burrows, bloating, refusal, dysphagia, nausea, vomiting and acid regurgitation) was used to evaluate the effectiveness of any treatment. These symptoms were assessed in week 2 and 4 of the study and then compared between the treatment groups.

important knowledge

The group that Aloe Vera syrup received showed a reduced frequency of all evaluated Gerd symptoms in weeks 2 and 4 compared to the starting value, without the impossible effects. Compared to both conventional treatment groups, aloe vera syrup was less effective in reducing the frequency of heartburn, bloating and belching. Although it may be less effective in these specific symptoms, aloe vera syrup has proven to be safe, effective and well-tolerated treatment option.
The results of this study show that aloe vera syrup is a safe, effective and well-tolerated treatment for frequent symptoms of Gerd.
Both groups treated with conventional medication (omeprazole and ranitidine) experienced a significant reduction in the frequency of all evaluated Gerd symptoms in both evaluation intervals compared to the initial value and compared to the aloe vera. However, in every group in conventional arms, 2 patients dropped due to side effects, while there were no dropouts in the Aloe Vera arm.

practical effects

The results of this study show that aloe vera syrup is a safe, effective and well-tolerated treatment for frequent symptoms of Gerd. While the symptoms were improved more reliably with acid -blocking drugs, this also seemed to have a greater risk of unbearable side effects.
Other studies support the use of aloe vera in the treatment of Gerd. A recently published study in Jama indicates that the pathogenesis of reflux esophagitis is more due to inflammation than chemical damage caused by gastric acid. 1 in 2007 a study published in 2007. Aloe vera has proven anti -inflammatory and antioxidant properties, 3 Therefore, these measures can contribute to his advantages in symptoms of Gerd. A study published in 2012 showed that Faringel, an antacid with aloe vera gel, reduced sodn burn in patients with erosive and non-erosive esophagitis. 4 In view of their anti-inflammatory effect, aloe Vera can be an advantage in long-term complications in connection with GERD such as barrett esophagus. So far, however, no clinical studies have been published on this topic. Numerous animal and human studies have positive effects of aloe vera in other gastrointestinal diseases such as z helicobacter pylori infection, 5-6 irritable bowel syndrome, 7 Colitis ulcerosa, 8-9 and Gastric ulcer. 10-11
Although aloe vera syrup was less effective compared to both conventional treatment options overall in reducing the evaluated Gerd symptoms, these types of medication have numerous side effects. Recent studies have associated the use of PPI with an increased risk of hip fractures. 12-13 Dementia, 14 Enteric infection and overgrowth, Fünfei myocardial infarction and cardiovascular overall. Kidney disease, 17 cell aging, 18 and others. Despite a milder side effect profile as PPIs, H 2 RA, associated with an increased risk of bacterial overgrowth, 19 rebound hyper-secretion, 20 and vitamin B12 deficiency. Cimetidin, also inhibit the liver enzyme cytochrome P450, which can significantly influence the metabolism of numerous medication.
In addition to aloe vera, many other natural therapies have been shown to have positive effects on Gerd, including changes in nutrition and lifestyle. 23-26 D limones, 27 Melatonin, 28 and Iberogast. Gerd are described. 30-32

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