Study: The influence of vitamin C on the endothelial function

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Reference Ashor AW, Lara J, Mathers JC, Siervo M. Effect of vitamin C on the endothelial function in health and illness: a systematic review and meta -analysis of randomized controlled studies. Atherosclerosis. 2014; 235; 1: (9-20). Study design Systemic review and meta-analysis of the Medline, Embase, Cochrane Library and Scopus databases (from the beginning to May 2013) for studies that meet the following criteria: 1) Randomized controlled study (RCT) with adult participants, only given vitamin C, and 3) studies that use the endothelial function (EF) using general methods Ultrasound, plethysmography and pulse wave analysis quantified participants The data were pooled from 44 RCTs of different sizes. Studies have been developed to ...
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Reference

Ashor AW, Lara J, Mathers JC, Siervo M. Effect of vitamin C on the endothelial function in health and illness: a systematic review and meta -analysis of randomized controlled studies. atherosclerosis. 2014; 235; 1: (9-20).

study design

Systemic review and meta-analysis of the Medline, Embase, Cochrane Library and SCOPUS databases (from the beginning to May 2013) for studies that meet the following criteria: 1) Randomized controlled study (RCT) with adult participants, only given vitamin C, and 3) studies that use the endothelial function (EF) Ultrasound, plethysmography and pulse wave analysis quantified

participant

The data was pooled from 44 RCTs of different sizes. Studies have been developed to evaluate the effect of vitamin C on EF in healthy volunteers and in patients with arteriosclerosis, diabetes and/or heart failure.

study parameters evaluated

All studies rated EF with common methods, including ultrasound, plillysmography and pulse wave analysis.

goal of the review

to determine whether a vitamin C supplementation has an effect on EF and if so, whether this effect is related to the state of health, the duration and/or the type of vitamin C transfer

important knowledge

The summary of the data showed a clear and significant benefit of a vitamin C supplement in quantities over 500 mg per day (standard mean difference [SMD]: 0.50, 95 % confidence interval [CI]: 0.34-0.66, p <. 001). It seemed that the participants had the greatest benefit with heart failure (SMD: 0.48, 95 % KI: 0.08-0.88, p <. 02). Those with diabetes and atherosclerosis also had significant improvements in EF (SMD: 0.52, 95 % CI: 0.21-0.82, p <. 001; SMD: 0.84, 95 % KI: 0.41, 1.26, p <. 001). Vitamin C had no influence on EF in healthy subjects. The improvements of the EF remained unaffected and unchanged when the study design, the duration, the Baseline plasma vitamin C concentration and the type of administration were taken into account. In the metargression analysis, the improvements of the EF seemed to be only dose-dependent (β: 0.00011; 95 % KI: 0.00001-0.00021, p =. 03).

practice implications

The endothel is in direct contact with our blood supply. As such, it is constantly under the influence of vasodilating and vascular -narrowing molecules in the blood and even contributes to this pool of opposing molecules. In the past, the endothel was considered a passive barrier between blood and blood vessels, but today we know that it is an active participant. EF is an essential part of maintaining the sensitive balance, which enables healthy blood vessels and the health of the tissue you flow through.
The current study only suggests that vitamin C should always be included in the protocols of our patients with cardiovascular diseases.
EF is of primary importance in the pathophysiology of numerous forms of cardiovascular diseases. 1 EF can be negatively influenced by a variety of known risk factors, including smoking, hypercholesterolaemia, hyperhomocysteineemia, hydroofing and diabetes mellitus. Additional factors that EF damage, which are not often taken into account in conventional medicine, but are often addressed in integrative practices, are heavy metal toxicity, organic toxins, chronic infections, inflammatory foods, intestinal dysbiosis and chronic stress. Important anatomical structure with an apparently endless supply of potentially harmful factors - by far no favorable situation.
In such circumstances, the availability of a therapeutic substance that improves EF and leads to better results, regardless of the situation or insult, would be highly desirable. Vitamin C appears more than qualified.
It is important to note that if the therapeutic approach used is open -minded, an attempt to tackle causal factors instead of suppressing symptoms, and the least harmful treatments are used at first, many therapies will probably be available. The current study only suggests that vitamin C should always be included in the protocols of our patients with cardiovascular diseases. This applies in particular to the essential vitamin status of vitamin C, its many other positive advantages, its omnipresent and its low costs.
Although the study analyzed here is important because it clearly shows the positive effects of vitamin C on EF, there was an additional motivation to concentrate on this study, in that all readers who are not yet familiar with the details of EF and their importance for them to draw attention to pathophysiology of cardiovascular diseases in particular and health in general

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