Study: lower the insulin -like growth factor 1 and live longer?

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Reference Milman S., Atzmon G., Huffman DM, et al. A low value of the insulin -like growth factor 1 predicts survival in people with exceptional durability. Aging cell. 2014; 13 (4): 769-771. EPUB 2014, March 12. Design in several animal models are low mirrors of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) associated with a longer lifespan. This study tries to confirm a similar effect in humans by measuring the IGF-1 levels in very durable people. Participants A group of 184 people in the 90s were divided into two groups based on the IGF-1 values: a group with low IGF-1 and a group with high IGF-1. It ...
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Reference

Milman S., Atzmon G., Huffman DM, et al. A low value of the insulin -like growth factor 1 predicts survival in people with exceptional durability. aging cell. 2014; 13 (4): 769-771. EPUB 2014, March 12.

Design

In several animal models, low mirrors of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are connected to a longer lifespan. This study tries to confirm a similar effect in humans by measuring the IGF-1 levels in very durable people.

participant

A group of 184 people in the 90s was divided into two groups based on the IGF-1 values: a group with low IGF-1 and a group with high IGF-1. There were 93 people in the group with low IGF-1 (mean 55 ng/ml) and 91 people in the group with high IGF-1 (mean 121 ng/ml). The average age was 96.8 years in the low group and 96.7 years in the high group.

target parameter

A Kaplan-Meier analysis of the total mortality was created and compared between groups with low and high IGF-1.

most important knowledge

very old women with IGF-1 values ​​below the median had a much longer survival time than women with values ​​above the median. This survival advantage was not observed in men. In both men and women with cancer in the history, lower IGF-1 level predicted a longer survival ( p <0.01). The IGF-1 level remained a significant predictor for the survival duration ( p = 0.01) in linear regression models after multivariabler adaptation in women and people with a cancer story ( p <0.01). This may be the first time that low IGF-1 values ​​can predict the life expectancy of exceptionally durable people.

effects on practice

The scientific understanding of IGF-1 is progressing rapidly. IGF-1 plays a central role in cell growth, differentiation, survival and the progression of the cell cycle. 1 An increase or reduction of the IGF-1 level could prove to be decisive for the change in the long-term results of our patient population, in particular the cancer survivors. IGF-1 is necessary for good health, but can be harmful in excess.
The best proof of this two-time effect can be found in people with Laron syndrome (LS), which is characterized by a lack of IGF-1 and resistance to growth hormones. Since 1966, when Zvi Laron, MD, described this disease for the first time, about 300 people with LS have been identified, of which a third of which lives in a single village in Ecuador, while most of the other is scattered over the Middle East. Available) a final size of only 39 to 54 inches. Their limbs, hands, feet, organs and facial features are all unusually small. 3 Obviously IGF-1 is necessary for growth and development. On the other hand, people with LS do not develop diabetes, rare or never to cancer and typically achieve a old age. 4 It is not only bad news, especially when it comes to cancer.
High IGF-1 levels are associated with an increased risk for most, if not all types of cancer. 5 including prostate, 6,7 Colorectal, 8 MULTIPLES Myelom Lung, 12 thyroid gland, 13 bone, 14 brain, 14 and ovarian cancer. If you are tall as a child, the risk for all types of solid tumors and malignant blood cancer increases later Life. 14.15 The data from this current study suggest that a low IGF-1 value can also improve the chances of survival of cancer patients.
The largest predictor of IGF-1 is protein intake through food. The higher the proportion of daily calories in protein (animal protein instead of vegetable protein), the higher the IGF-1 level of a person. This could explain why a high protein content in food is associated with numerous diseases, in particular cancer and diabetes.
This is the explanation that Levine et al. give in their recent study (link away). A low protein intake in middle age is associated with less mortality. A protein -rich diet is associated with an increase in total mortality by 75 % and a four -fold increase in cancer risk risk. What makes things even more complicated is that Levine reported that the connection between low IGF-1 values ​​and mortality changes with age. Your data suggests that a high protein content in food is associated with a lower cancer diagnosis and less mortality in patients over 65 years.
For obvious reasons, the reduction of IGF-1 could prove useful in cancer treatment 17 at least in humans under the age of 65.
Nowadays, various strategies for reducing IGF-1 are used: calorie restriction, movement and fasting. 18-21 reducing protein can be reduced in humans than calorie restriction. IGF-1 value connected. 23 Maybe this is an argument for consuming green leafy vegetables: How naturally you can be? The use of proton pump inhibitors is also connected to low IGF-1 levels. 24 Take green leafy vegetables and omeprazole? Not so naturopathic!
For certain patients, the maintenance of higher IGF-1 levels can be important. IGF-1 protects the brain from aging, reduces the stroke and Alzheimer's risk. 25 can help stroke patients recover faster, 26.27 and prevent osteoporosis.

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