Study: Association between Mediterranean diet and increased telomer length

Veröffentlicht:

Von:

Referenz Crous-Bou, M., Fung, T. T., Prescott, J., et al. Mediterrane Ernährung und Telomerlänge in der Nurses‘ Health Study: Populationsbasierte Kohortenstudie. BMJ. 2014 Dez 2;349:g6674. Design Populationsbasierte Kohortenstudie Teilnehmer Die Teilnehmer waren 4.676 krankheitsfreie Frauen aus verschachtelten Fall-Kontroll-Studien innerhalb der Nurses‘ Health Study, einer laufenden prospektiven Kohorte von 121.700 Krankenschwestern, die sich 1976 einschrieben, mit einer Untergruppe von 32.825 Frauen, die zwischen 1989 und 1990 Blutproben lieferten. Ergebnismessungen Die Assoziation zwischen selbstberichteten mediterranen Ernährungsdaten und relativen Telomerlängen in peripheren Blutleukozyten, gemessen durch quantitative Echtzeit-Polymerase-Kettenreaktion Wichtige Erkenntnisse Längere Telomere wurden mit einer stärkeren Einhaltung der Mittelmeerdiät in Verbindung gebracht. Nach Bereinigung …
Reference Crous-Bou, M., Fung, T. T., Prescott, J., et al. Mediterranean nutrition and telomer length in the Nurses' Health Study: Population -based cohort study. BMJ. 2014 Dec 2; 349: G6674. Design population-based cohort study participants were 4,676 disease-free women from nested case control studies within the Nurse 'Health Study, an ongoing prospective cohort of 121,700 nurses who were written to in 1976, with a sub-group of 32,825 women who delivered blood rehearsals between 1989 and 1990. Results measurements The association between self-reported Mediterranean nutritional data and relative telomer lengths in peripheral bloodleukocytes, measured by quantitative real-time polymerase chain reaction, Important telomeres have been associated with a greater compliance with the Mediterranean diet. After cleanup ... (Symbolbild/natur.wiki)

Reference

crous-bou, M., Fung, T. T., Prescott, J., et al. Mediterranean nutrition and telomer length in the Nurses' Health Study: Population -based cohort study. BMJ. 2014 Dec 2; 349: G6674.

Design

population -based cohort study

participant

The participants were 4,676 disease-free women from nested case control studies within the Nurse 'Health Study, a ongoing prospective cohort of 121,700 nurses who wrote to 1976, with a sub-group of 32,825 women who delivered blood samples between 1989 and 1990.

result measurements

The association between self-reported Mediterranean nutritional data and relative telomer lengths in peripheral bloodleukocytes, measured by quantitative real-time polymerase chain reaction

important knowledge

longer telomeres were associated with a greater compliance with the Mediterranean diet. After cleaning up potential disruptive factors (e.g. physical activity, smoking, body mass index), the average Z-values ​​of the telomer length were ‒0.038 (standard error: 0.035) for the lowest values ​​of the Mediterranean diet and 0.072 (0.030) for the highest group ( p =. 004).

practice implications

since Hermann Müller first discovered her in 1938, fascinated telomeres researchers. The protective caps at the end of the chromosomes, telomeres, protect the physical integrity of chromosomes. An accelerated shortening of the telomeres was associated with inflammation, chronic diseases and a reduced life expectancy. 1,2 telomerase is an enzyme that preserves the telomer by maintaining its length. Research shows that modifiable factors such as nutrition can influence telomericides and telomerase activity.
The recommendation of a Mediterranean diet in conjunction with lifestyle such as regular exercise and coping with stress seems to be a solid fundamental advice that we can give patients in order to promote optimal durability.
A key question that most patients ask themselves is: "What is the best diet?" While all practitioners individualize their advice and have favorite recommendations, it is difficult to argue against a full -scale food in the Mediterranean style as the basis for individualization. With its emphasis on fully -fledged, unprocessed foods, fruits, vegetables, nuts and healthy fats, the Mediterranean diet has important antioxidant, anti -inflammatory and telomer -protecting factors. In addition to this latest study, other studies have shown that components of the Mediterranean diet can have a positive impact on the length and stability of the telomeres. In 2012, Marcon et al. Both longer telomeres ( p =. 003) and higher telomerase activity ( p = 0.013) for older subjects who maintained the Mediterranean diet most.
regardless-or perhaps partly due to-the telomer status, the Mediterranean diet is associated with a significant reduction in the overall mortality and the disease-specific mortality by cardiovascular diseases and cancer. 6 published in 2013 published in 2013. The largest prospective randomized controlled study that examined the effects of the Mediterranean diet on cardiovascular diseases. Known as predimed (for Prevención con Dieta Mediterránea or Prevention with Mediterranean Diet) found the researchers that the Mediterranean diet, supplemented with extra native olive oil or nuts, was connected with a 30%reduction in the heart attack risk. Rel = "NOFOLLOW NoOpener" Target = "_ blank" http://naturalmedicinejournal.com/journal/2015-02/prevevenci%C3%B3n-con-dieta-Mediterr%C3oken Predimed.] Babio et al. Published a secondary analysis of the predimed study and found that people who adhered to the Mediterranean diet also showed a significant decrease in both central obesity and the high sober glucose level ( p =. 02).
It is important to note that the diet is only an epigenetic factor that is associated with longer telomers. In 2008, Ornish et al. Showed that a healthy diet in combination with moderate aerobic training, stress management and specific nutritional supplement increased the telomerase activity over a period of 3 months by almost 30 %.9 In 2012, Sun et al Women led in the nurse 'Health Study that women who did not smoke, a healthy body weight, regularly Sport drove, had a moderate alcohol consumption and had a healthy Mediterranean diet, had a 31.2%increase in telomer length.
This latest study contributes to the growing evidence that clearly indicate that we can influence biochemically and epigentically how our genes behave in an effective way. The recommendation of a Mediterranean diet in conjunction with life habits such as regular exercise and coping with stress seems to be a solid fundamental advice that we can give patients in order to promote optimal longevity.
Note from the publisher: Click here to read a peer review article about telomeres and optimal health of Lise Alschuler, ND, Fabno, here .

  1. Blasco Ma. Telomers and human diseases: aging, cancer and more. Nat. Rev. Genet. 2005; 6 (8): 611-622.
  2. Haycock PC, Heydon EE, Kaptoge S, et al. Leukocyten telomer length and risk of cardiovascular disease: systemic review and meta-analysis. bmj. 8. July 2014; 349: G4227.
  3. Sun Q, Shi L, Prescott J, et al. Healthy lifestyle and leukocyte stelomer length in US women. plus one. 2012; 7 (5): E38374.
  4. Marcon F, Siniscalchi e, Crebelli r, et al. Nutritional telomer reduction and chromosome stability. mutagenese. 2012; 27 (1): 49-57.
  5. Boccardi V, Esposito A, Rizzo MR, Marfella R, Barbieri M, Paolisso G. Mediterranean diet, telomer maintenance and state of health in older people. plus one. 2013; 8 (4): E62781.
  6. Sofi F, Cesari F, Abbate R, Gensini GF, Casini A. Compliance with the Mediterranean diet and state of health: meta -analysis. BMJ. September 11, 2008; 337: A1344.
  7. Estruch R, Ros E, Salas-Salvadó J, et al. Primary prevention of cardiovascular diseases with a Mediterranean diet. n Engl. J med. 2013; 368 (14): 1279-1290.
  8. n. Babio, E. Toledo, R. Estruch et al. Mediterranean diets and status of the metabolic syndrome in the randomized predimed study. cmaj. 2014; 186 (17): E649-E657. Epub October 14, 2014.
  9. d. Ornish, J. Lin, J. Daubenmier et al. Increased telomerase activity and comprehensive changes to the lifestyle: a pilot study. lancet oncol. 2008; 9 (11): 1048-1057.