Rotavirus vaccination lowers the risk of diabetes in children

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Cover Perrett KP, Jachno K., Nolan TM, et al. Association of the rotavirus vaccination with the incidence of type 1 diabetes in children. Jama Pädiatr. 2019; 173 (3): 280-282. Designed retrospective analysis objective comparison of the incidence of newly diagnosed type 1 diabetes mellitus (T1D) in Australian children in the 8 years before and after the introduction of routine oral rotavirus vaccination participants. This was a nationwide study that was carried out in Australia. The study included data from Australian children in which T1D was diagnosed between 2000 and 2015. During this period, 16,159 new cases of T1D were diagnosed. This corresponds to an average rate of 12.7 (95 % confidence interval [CI]: 11.0-14.8) ...
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reference

Perrett KP, Jachno K., Nolan TM, et al. Association of the rotavirus vaccination with the incidence of type 1 diabetes in children. Jama Pädiatr . 2019; 173 (3): 280-282.

draft

observing, retrospective analysis

objective

Comparison of the incidence of newly diagnosed type 1 diabetes mellitus (T1D) in Australian children in the 8 years before and after the introduction of routine oral redavirus vaccination

participant

This was a nationwide study that was carried out in Australia. The study included data from Australian children in which T1D was diagnosed between 2000 and 2015. During this period, 16,159 new cases of T1D were diagnosed. This corresponds to an average rate of 12.7 (95 % confidence interval [CI]: 11.0-14.8) cases per 100,000 children.

Intervention

Vaccination against redavirus for all infants from 6 weeks began in Australia in May 2007. Children are vaccinated between the ages of 2 and 4 months.

study parameters evaluated

In Australia, the national diabetes services provides subsidized deliveries for glucose sets and insulin for patients. This register was used to identify newly diagnosed cases of T1D.

Primary result measurement

Incidence of T1D in children before and after routine vaccination

important knowledge

In children aged 0 to 4 years, the number of newly occurred cases of T1D decreased by 14 % (Rate Ratio: 0.86; 95 % KI: 0.74–0.99; p = 0.04) after the introduction of oral redavirus vaccine in 2007.

practice implications

The incidence of T1D has increased in the past few years, both in Australia.

This report could be the first proof that the declining incidence with the introduction of routine redavirus vaccinations coincides. The decline in diagnosis of diabetes only occurred in the age cohort of children who were born after the introduction of the vaccine, results that correspond to the hypothesis that it protects the vaccine from the development of T1D. Older children who had not been vaccinated showed no similar decline in disease incidence.

The decline in diagnosis of diabetes only occurred in the age cohort of children who were born after the introduction of the vaccine, results that match the hypothesis that this vaccine protects against the development of T1d

A rotavirus infection is generally associated with gastrointestinal symptoms, but there is a growing consensus that their effects are systemic and an increased risk of autoimmune diseases. A complete rotavirus vaccination is associated with an 18- to 21 percent reduction in seizures that require a hospital stay in the year after vaccination.

1998 Len Harrison was the first to report that in children after a rotavirus infection, immune markers for diabetes occurred. 6 Newer studies in laboratory models indicate that a rotavirus infection of the pancreatic gland triggers an immune attack on the insulin-producing cells, similar to the pathogenesis of T1d. 7

If a Rotavirus infection increases the risk of diabetes, it is only fair to ask whether the vaccine could do the same. Researchers in Finland asked this question and reported in May that the Rotavirus vaccine does not seem to increase the risk of diabetes. A large placebo-controlled study showed no indication of an increased risk of diabetes in children who received the Rotavirus vaccine. In fact, there was a trend towards a lower risk (approx. 7 %), but this difference did not achieve any statistical significance. Your data showed a statistically significantly lower risk of developing celiac disease; Children who received the Rotavirus vaccination had a 50 % lower relative risk of celiac disease compared to the placebo group.

In the May issue of the Natural Medicine Journal, Jody Stanislaw, ND, CDE, introduced us to a concept that she calls "beta cell conservation". 9 In the early diabetes or in the latent autoimmundiabetes of adults (LADA) there is a period in which a partial pancreatic function is preserved. Stanislaw claims that this function can be preserved through reasonable nutrition, movement and nutritional supplements. You have to ask yourself whether this Rotavirus vaccine could also prove to be useful to protect the pancreas and to slow down the loss of function from further autoimmune attacks.

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