Revolutionary study reveals: How to repair Polgins and PLK1 in the mitosis to double -stranded breaks

Revolutionary study reveals: How to repair Polgins and PLK1 in the mitosis to double -stranded breaks

Title: New study shows: Polgins are phosphorylated by PLK1 to repair double -strand breaks during the mitosis

subtitle: breakthrough in research on the DNA repair at a cellular level

Date: [Date]

The human DNA is exposed to numerous pollutants and damage every day that can affect our cells. To repair this damage, the human body has developed various mechanisms across evolution. A recently published study entitled "Polgin Is Phosphorylated by Plk1 to Repair Double-Strand Breaks in Mitosis" has now provided new insights into an important repair mechanism.

The renowned specialist magazine "Nature" published the groundbreaking study carried out by an international team of scientists. The researchers discovered that the enzyme pole pole is phosphorylated during the mitosis by a signal protein called PLK1 to repair double -strand breaks in the DNA.

Double strand breaks, in which both strands of the DNA are damaged, are the most dangerous type of DNA damage. They can lead to serious genetic changes and ultimately increase the risk of cancer and other diseases. Therefore, the efficient repair of double -strand breaks is of crucial importance for the preservation of cellular integrity and health.

pola has already been identified in previous studies as an important enzyme when repairing DNA doubles. However, the new study provides for the first time that PLK1 is phosphorylated in order to enable this repair process. PLK1 is a key protein that is involved in various cellular processes, including cell division and DNA repair.

The researchers carried out extensive experiments with human cell cultures in order to examine the effects of the phosphorylation of Polgins by PLK1. They found that a blockade of phosphorylation led to a significantly slower repair of DNA double breeds. This indicates that the phosphorylation of Polgins by PLK1 is a decisive step in the efficient repair of DNA damage.

The knowledge from this study could possibly open new ways for the development of therapies to treat genetically related diseases and cancer. An improved understanding of the molecular mechanisms of the DNA repair can help to develop effective medication that can promote or inhibit these processes.

However, the scientists emphasize that further research is necessary to understand the exact effects of the phosphorylation of Polgins by PLK1. Nevertheless, this study is a milestone in the research of the DNA repair and offers promising approaches for future therapeutic approaches.

Source: [http://www.nature.com/articles/s41586-06506-6]

The study clearly shows that research into the DNA repair is of crucial importance in order to better understand the underlying mechanisms of genetic diseases. The discovery that PLK1 is phosphorylated by PLK1 to repair double -strand breaks during the mitosis opens up exciting opportunities for the development of new treatment approaches. It remains to be seen how this findings will influence future research and innovative therapies.