New study reveals groundbreaking method for functionalization of alcohols in organic chemistry

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Titel: Neue Studie ermöglicht innovative C-H-Funktionalisierung mithilfe von Alkoholen als Leitstrukturen Untertitel: Forscher erreichen Durchbruch in der Katalyse zur direkten Synthese organischer Moleküle In der organischen Chemie stellt die Funktionalisierung von C-H-Bindungen in organischen Molekülen einen der direktesten Ansätze für die chemische Synthese dar. Dank der jüngsten Fortschritte in der Katalyse ist es nun möglich, natürliche chemische Gruppen wie Carbonsäuren, Ketone und Amine zur Steuerung und Lenkung der C(sp3)-H-Aktivierung zu nutzen (1,2,3,4). Allerdings blieben Alkohole, welche zu den häufigsten funktionellen Gruppen in der organischen Chemie gehören (5), aufgrund ihrer geringen Affinität zu Übergangsmetall-Katalysatoren bislang schwer zugänglich (6,7). Doch nun berichten …
Title: New study enables innovative C-H functionalization with the help of alcohols as control structures Subtitles: Researchers achieve breakthrough in catalysis on the direct synthesis of organic molecules in organic chemistry, the functionalization of C-h bonds in organic molecules is one of the most direct approaches to chemical synthesis. Thanks to the recent progress in catalysis is now possible to use natural chemical groups such as carboxylic acids, ketones and amine to control and steer the C (SP3) -H activation (1.2.3.4). However, alcohols, which are among the most common functional groups in organic chemistry (5), have so far been difficult to access due to their low affinity to transition metal catalysts (6.7). But now report ... (Symbolbild/natur.wiki)

Title: New study enables innovative C-H functionalization using alcohols as control structures

subtitle: Researchers achieve breakthrough in catalysis on the direct synthesis of organic molecules

In organic chemistry, the functionalization of C-H bonds in organic molecules is one of the most direct approaches to chemical synthesis. Thanks to the recent progress in catalysis, it is now possible to use natural chemical groups such as carboxylic acids, ketones and amine to control and control the C (SP3) -H activation (1,2,3,3,4). However, alcohols, which are among the most common functional groups in organic chemistry (5), have so far been difficult to access due to their low affinity to transition metal catalysts (6.7).

But now scientists report a pioneering study in which they describe ligands that enable the alcohol-oriented arylation of δ-c (SP3) -H bonds. The L-typical hydroxyl coordination on palladium is stabilized by a balanced load and a secondary coordination sphere with hydrogen bridge binding. This result could be demonstrated by structural and impact relationship studies, computer-aided modeling and crystallographic data. The method described makes it easier to set up the key transition state for splitting the C-H bond (8,9,10,11,12,13).

In contrast to previous studies on C-H activation, in which secondary interactions were used to control the selectivity in the context of established reactivity, this report shows the feasibility of the use of secondary interactions in order to enable demanding, previously unknown reactivities and to improve substrate catalyst affinity.

The study presented thus opens up completely new possibilities in organic synthesis. By using alcohols as control structures, researchers can now access a wide range of connections that were not easy to access before. This is a significant progress that could promote the development of innovative natural remedies and other therapeutic agents.

The complete study can be viewed here: (link removed)