Informed prostate cancer patients regret the treatment less

Informed prostate cancer patients regret the treatment less
reference
Hoffman RM, LO M, Clark Ja, et al. Regarding the treatment decision in long -term survivors of localized prostate cancer: Results of the prostate Cancer Outcomes Study. j clin oncol. 2017; 35 (20): 2306-2314.
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FOLLOW-UP-UM fraged data from a large, population-related cohort study, which is known as the prostate Cancer Outcomes Study and was originally published in Journal of the National Cancer Institute .
study population
934 men who were treated in various US cities between October 1994 and 1995 and were part of a cohort who filled up basic and 15-year surveys. They were diagnosed with localized prostate cancer, and at 59 % it was classified as a disease with little risk, which was diagnosed before the age of 75. Of the total of 934 patients, 696 were dealt with with an initial radical prostate, 146 received initial radiation therapy and 92 were treated with one of the two observations (no treatment) or and androcodation therapy within 1 year after diagnosis.
results measured
Multivariabl logistical regression analyzes were used to identify factors associated with repentance. A 15-year follow-up survey was used to determine several key factors, including:
- Demography
- socio -economic status
- regret of the treatment decision
- informed decision making
- General and illness -specific quality of life
- health care
- PSA concerns
- life prospects
important knowledge
The return rate of the survey in the 15-year follow-up period was 69.3 %. Most of the respondents had undergone radical prostate, with 10.8 % of the survey answers of patients who were treated conservatively with Watchful Waiting or androgen withdrawal therapy. Overall, less than 15 % expressed their regret about the treatment decision, with the largest proportion (16.6 %) of regret to be regretted by those who had undergone radiation therapy. The men who were older and felt that they had made a well -founded treatment decision also regretted the least. The men who reported, symptoms with intestinal function, sexual function and higher PSA values regretted the most.
practice implications
Interestingly, the same researchers surveyed the same participants of the prostate cancer study 2 years after the treatment, so that 2 sentences of data points must now be taken into account: 2 years (study of 2003)regret is highly associated with lack of knowledge of side effects of treatment such as intestinal, urine and sexual dysfunction, which can have a negative impact on the quality of life after treatment.
This study and previous research results show that regret is highly associated with a lack of knowledge of unwanted treatment effects such as intestinal, urine and sexual dysfunction that can have a negative impact on the quality of life after treatment. It is clear that men who took on a more active role in their treatment decisions found fewer regrets. showed that men who used a navigator to support the treatment process showed significantly less repentance 6 months after the treatment than those who did not use navigation.
In this study, men experienced in this study who treated their cancer more conservative with observing waiting, which is also called active surveillance, and whose PSA value had normalized without recurrent, the slightest degree of repentance, possibly due to the lack of side effects and problems with the quality of life. These researchers see this an opportunity to inform men with localized prostate cancer about the option of active surveillance. Research actually shows that active monitoring had similar results and mortality compared to initial radiation therapy and operation. Due to the lack of treatment of treatment, active monitoring has turned out to be a standard treatment option for men with prostate cancer with very low and low risk. 7.8 In this present study, it is of the opinion that their results are "contemporary for men with cancer with little risk that is encouraged to consider active surveillance".
As a radio oncologist, it is important to me to note that the toxicity of treatment can vary over time. For example, this cohort was treated before the advent of the intensity-modulated radiation (IMRT), which improved both short and long-term side effects of radiation therapy. Over time, surgical progress has also been made, such as: B. the robot -based prostate. In addition, active monitoring as a discrete protocol 1994-95 did not formally exist. Regardless of these therapeutic improvements, it is important to know that the conventional treatments we administered can sometimes cause long -term problems with the quality of life, such as: B. urinary incontinence or sexual and intestinal dysfunction. It is also a challenge to predict long -term effects that may not dissolve. I work with patients to determine their risk tolerance, their personal and psychological values and other considerations about the quality of life to help them find the right way. A correct way for a 50-year-old healthy man is probably different from the way for an unhealthy 78-year-old. We go through the options and discuss factors that are completely under their control - how they eat, move their bodies and deal with their stress. We discuss that there is good data for these controllable factors to influence the progression rates of prostate cancer.
The clinical take-home message is that all men deserve to be well informed about the complexity and nuances of any treatment option for prostate cancer. Patients must be advised to make decisions on the basis of many factors, including the effects of treatment, problems with the quality of life, relapse risk, healthy living habits and other aspects of care, to ensure that the final decision matches the patient's values and expectations. 10 If we do men who were diagnosed with prostate cancer, their treatment options helped by this lens Consider, we can regret it both short and long-term.
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- Fowler FJ Jr., Gallagher PM, Drake KM, et al. Decision -making Dissonance: Assessment of an approach to measuring the quality of surgical decision -making. jt comm J Qual Patient Saf. 2013; 39: 136-144.