Nutrition, dietary supplements and Parkinson's disease

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Reference Mischley LK, Lau RC, Bennett RD. The role of diet and supplements in the progression of Parkinson's disease. Oxide Med Cell Longev. 2017;2017:6405278. Design This study was a cross-sectional analysis of an online platform created by the author (Laurie Mischley, ND, PhD). The platform enrolls Parkinson's patients in a longitudinal research study. Patients self-report their Parkinson's symptoms, their food diary, and their intake of nutritional supplements. Participants The study population included 1,053 individuals with idiopathic Parkinson's disease; 93% of participants were Caucasian, with an average of 5.2 years since diagnosis. Study parameters assessed Parkinson's disease symptoms, severity of progression, diet (after recall), and supplement use; The …

Bezug Mischley LK, Lau RC, Bennett RD. Die Rolle von Ernährung und Nahrungsergänzungsmitteln beim Fortschreiten der Parkinson-Krankheit. Oxid Med Cell Longev. 2017;2017:6405278. Entwurf Diese Studie war eine Querschnittsanalyse einer Online-Plattform, die von der Autorin (Laurie Mischley, ND, PhD) erstellt wurde. Die Plattform nimmt Parkinson-Patienten in eine Längsschnittforschungsstudie auf. Die Patienten berichten selbst über ihre Parkinson-Symptome, ihr Ernährungstagebuch und die Einnahme von Nahrungsergänzungsmitteln. Teilnehmer Die Studienpopulation umfasste 1.053 Personen mit idiopathischer Parkinson-Krankheit; 93 % der Teilnehmer waren Kaukasier, mit einem Durchschnitt von 5,2 Jahren seit der Diagnose. Studienparameter bewertet Parkinson-Symptome, Schweregrad des Fortschreitens, Ernährung (nach Rückruf) und Einnahme von Nahrungsergänzungsmitteln; Die …
Reference Mischley LK, Lau RC, Bennett RD. The role of diet and supplements in the progression of Parkinson's disease. Oxide Med Cell Longev. 2017;2017:6405278. Design This study was a cross-sectional analysis of an online platform created by the author (Laurie Mischley, ND, PhD). The platform enrolls Parkinson's patients in a longitudinal research study. Patients self-report their Parkinson's symptoms, their food diary, and their intake of nutritional supplements. Participants The study population included 1,053 individuals with idiopathic Parkinson's disease; 93% of participants were Caucasian, with an average of 5.2 years since diagnosis. Study parameters assessed Parkinson's disease symptoms, severity of progression, diet (after recall), and supplement use; The …

Nutrition, dietary supplements and Parkinson's disease

Relation

Mischley LK, Lau RC, Bennett RD. The role of diet and supplements in the progression of Parkinson's disease.Oxide Med Cell Longev. 2017;2017:6405278.

Draft

This study was a cross-sectional analysis of an online platform created by the author (Laurie Mischley, ND, PhD). The platform enrolls Parkinson's patients in a longitudinal research study. Patients self-report their Parkinson's symptoms, their food diary, and their intake of nutritional supplements.

Participant

The study population included 1,053 individuals with idiopathic Parkinson's disease; 93% of participants were Caucasian, with an average of 5.2 years since diagnosis.

Study parameters assessed

Parkinson's disease symptoms, severity of progression, diet (post-recall), and supplement use; Symptoms were assessed using patient-reported scores on the Parkinson's Disease Scale (PRO-PD), an outcome tool created by the author.

Primary outcome measures

The analysis compared each patient's disease progression rate with their diet and supplement intake to look for statistically significant associations.

Key insights

The following results show which foods and supplements are significantly (P<0.05), which are associated with slower progression or faster progression of Parkinson's symptoms.

DELAYED PROGRESS FASTER PROGRESS
Fresh fruits and vegetables Canned fruits and vegetables
Nuts and seeds Diet and non-diet soda
Not fried fish Fried foods
olive oil beef
Wine Ice cream
Coconut oil yogurt
Fresh herbs and spices Cheese
Coenzymes Q10 iron
Fish oil

Practice implications

Parkinson's disease is an extremely debilitating condition and is poorly understood.1Traditional options are limited, and studies suggest that many Parkinson's patients turn to diet, naturopathy and supplements to slow the disease's progression.2However, little is known about their effectiveness. The present study is an attempt to shed light on the effects of diet and supplement use on the progression of Parkinson's disease.

Many of the results of this study aren't all that surprising. Most foods associated with delayed progression are elements of a Mediterranean diet. This type of diet has anti-inflammatory effects and has been shown to be associated with fewer cases and later onset of Parkinson's disease.3Fish oil has been repeatedly shown to be neuroprotective4and indeed, this study found a link between fish consumption and delayed progression of Parkinson's symptoms.

Most foods associated with delayed progression are elements of a Mediterranean diet.

The connection between eating canned foods and faster progression of Parkinson's disease is intriguing. Because this association remained after adjusting for income, it is less likely to be related to limited access to health care (which is often associated with low income status). Could there be something in the cans themselves? The authors postulate that bisphenol A (BPA), or aluminum, a known neurotoxin,5could be subject to contributions.

The association of soda consumption with faster disease progression may be due to certain neurotoxins such as aspartame.6The association with fried foods may be related to lipid peroxidation. The association of ice cream, yogurt, and cheese with rapid progression is consistent with previous research; A meta-analysis of dairy intake and Parkinson's disease demonstrated a dose-dependent association between dairy intake and Parkinson's disease.7Both iron supplements and beef, which has a high iron load, were associated with rapid progression in this study, consistent with the notion that iron drives symptom progression due to its oxidative nature.8

While coenzyme Q10 (CoQ10) showed early promise in Parkinson's disease, more recent randomized controlled trials have shown no benefit.9It is interesting that the association between delayed progression and coenzyme Q10 in this study was no longer statistically significant after income adjustment. The author postulates that CoQ10, an expensive dietary supplement, may be a surrogate for high income status, which itself was associated with delayed progression, perhaps due to better access to healthcare.

This study has some excellent strengths. The researchers adjusted all results for age, gender, years since diagnosis and income level, and the results give us our first clues about the effect of diet and supplements on Parkinson's disease. Of course, there are limitations to this study. As a cross-sectional analysis, conclusions from the study design are limited. This study is a longitudinal study and this publication is preliminary and not exhaustive. The researchers didn't correct that eitherPvalues ​​for multiple comparisons, so it is possible that some statistically significant associations are spurious.

In summary, this study presents some interesting preliminary results regarding diet and supplements for Parkinson's disease. This is an important first step that will be followed by further work by the study authors and other researchers.

  1. Kalia LV, Lang AE. Parkinson-Krankheit. Lanzette. 2015;386(9996):896-912.
  2. Ren S, Cooper K, Cooper JA, Smith HT, Shaikh S. Eine systematische Überprüfung und Netzwerk-Metaanalyse pharmakologischer Therapien für Patienten mit fortgeschrittener Parkinson-Krankheit. Wert heilen. 2014;17(7):A390.
  3. Alcalay RN, Gu Y, Mejia-Santana H, Cote L, Marder KS, Scarmeas N. Der Zusammenhang zwischen der Einhaltung der Mittelmeerdiät und der Parkinson-Krankheit. Bewegung Disord. 2012;27(6):771-774.
  4. da Silva TM, Munhoz RP, Alvarez C, et al. Depression bei der Parkinson-Krankheit: eine doppelblinde, randomisierte, placebokontrollierte Pilotstudie zur Supplementierung mit Omega-3-Fettsäuren. J Affect Disord. 2008;111(2-3):351-359.
  5. Campdelacreu J. Parkinson-Krankheit und Alzheimer-Krankheit: Umweltrisikofaktoren. Neurologie. 2014;29(9):541-549.
  6. Rycerz K, Jaworska-Adamu JE. Auswirkungen von Aspartam-Metaboliten auf Astrozyten und Neuronen. Folia Neuropathol. 2013;51(1):10-17.
  7. Jiang W, Ju C, Jiang H, Zhang D. Aufnahme von Milchprodukten und Risiko der Parkinson-Krankheit: eine Dosis-Wirkungs-Metaanalyse prospektiver Kohortenstudien. Eur J Epidemiol. 2014;29(9):613-619.
  8. Medeiros MS, Schumacher-Schuh A, Cardoso AM, et al. Eisen und oxidativer Stress bei der Parkinson-Krankheit: eine Beobachtungsstudie zu Verletzungsbiomarkern. Plus eins. 2016;11(1):e0146129.
  9. Parkinson-Studiengruppe QE3 Ermittler, Beal MF, Oakes D, et al. Eine randomisierte klinische Studie mit hochdosiertem Coenzym Q10 bei Parkinson im Frühstadium: kein Nutzennachweis. JAMA Neurol. 2014;71(5):543-552.