Curcumin and bone density

reference

riva a, toogni s, giacomelli l, et al. Effects of a nutritional supplement based on curcumin for asymptomatic subjects with low bone density: a preliminary 24-week nutritional supplement study. EUR. Rev. med. Pharmacol. Sci . 2017; 21: 1684-1689.

study design

A 24-week open pilot study to supplement the man [ editor’s Note: The Study’s Authors Clarify, “Supplement Studies Define the Field of Activity of Pharma Standard Supplements and their possible preventive, pre-therapeutic applications. ' Supplementary Data to be compared with the best of the best Available Management Plans. ”]

learning objectives

Comparison of the effectiveness and safety of supplementation with curcumin phytosome plus standard treatment of osteopenia with standard treatment alone

participant

fifty -seven older men (average age 71 years) who were otherwise healthy (BMI <25 kg/m2) and in which osteopenia was diagnosed using DXA. The study participants decided to participate in one of the standard treatments (i.e. a nutritional assessment, followed by a diet that contains sufficient vitamin D, vitamin C and calcium, and a regular training program that consists of 4 times a week strength training, walking or running; n = 28) or standard management with the addition "an addition" (n = 29).

exclusion criteria were a diagnosis of high blood pressure or hypercholesterolemia. All subjects also had normal erythrocy tensedism rate (ESR) and C-reactive protein (CRP) mirror. No placebo was given in this open study.

Intervention

The addition consisted of 1,000 mg curcumin phytosome (meriva), which was administered daily as a single dose.

target parameter

The bone density measurement was assessed with ultrasound. In particular, the Kalkaneus densiometry was carried out using a clinical Sahara bone monometer (Hologic Inc., Marlborough, MA, USA), and the fifth digit and the pine were carried out using a semi-quantitative, high-resolution ultrasound scanner (Preirus, Hitachi, Tokio, Japan).

The bone density was determined after 4, 12 and 24 weeks and compared with the starting values ​​of the group and the results of the other group.

important knowledge

In the 12-week and 24-week follow-up examination, the bone density was significantly improved ( p <0.05) compared to the starting value on the lime, upper jaw and fifth finger. The ultrasound permeability of the heel leg (according to the increase in bone density) decreased by 18.4 % or 21 % in week 12 and 24 ( p ≤05). Parameters of the fifth number and the upper jaw also had statistically significant ( p ≤0.05) improvements in week 12 (6.9 % or 2.3 %) and week 24 (7.1 % or 4.8 %). Those who only received the standard supply had no significant changes in the bone density parameters. No side effects or compatibility problems were found.

practice implications

doctors who consider treatments to improve bone density in patients with osteopenia probably close nutrients such as calcium, magnesium, vitamin D, vitamin K and omega-3 fatty acids.

curcumin may not come to mind as the standard addition to this regime, but this study of older men with a reduced bone density suggests that it might be like that. It should be noted that the curcumin phytosome preparation of Meriva contains 20 percent curcumin extract, 40 percent phosphatidylcholine and 40 percent cellulose. Thus, the daily dose cast was 200 mg.

The phytosome formulation can, however, have unique absorption properties. In a comparison of study by curcumin with (meriva) and without phytosome in 9 healthy volunteers, Cuomo and colleagues found that 200 mg Meriva had circulating curcuminoid levels, which corresponded to 5.8 grams of comparable dry powder. This represents 29 times higher values, which indicates that the phytosome has increased the absorption and/or the limited metabolism of the curcumin.

The significantly improved bone density in the curcumin group, which was found in the 12- and 24-week examinations, compared to the control group, indicates that curcumin could be a valuable addition to the standard treatment of the reduced bone density. While curcumin extracts have shown an effectiveness in preventing bone density loss in test animals, ^{2-5 This is the first study in humans that show an improved bone density after adding curcumin. A plausible mechanism could be the activity of curcumin when inhibiting osteoclastic bone absorption, possibly due to its known disturbance of the signal transmission of the core factor Kappa B (NF-KB), which is also the main mechanism of the anti-inflammatory effect of curcumin.}

The wording of this product is of interest, since the Hordaland health study showed that dietary choline is directly related to the bone mineral density. ^{7.8 A follow-up study with a similar structure, but with a placebo, consisting of cellulose and phosphatidyl cholin, would help to strengthen the evidence.}

This was a preliminary study that should be repeated in a larger group, but it seems that we can add osteopenia to the list of clinical states. ⁹ Delayed sore muscles after training, ^{10 arthrosis, 11 Prostatehyperplasia, 12 Sarcopenia, 13 uveitis, 14 Fifteen fatty liver, fifteen and quality of life in cancer treatment. 16}

Explanation on conflicts of interest

It should be pointed out that three of the authors of the article discussed here are employed by Meriva, the Indena Corporation. A fourth author works as a consultant for the company. In addition, one of the authors, F. Franceschi, MD, deputy editor of the magazine in which this article was published. I am also employed by a company, Thorne Research, which benefits from the sale of Meriva.