Anthocyans for cardiovascular health

Anthocyans for cardiovascular health
reference
Zhang X, Zhu Y, Song F, et al. Effects of cleaned anthocyanine supplementation on platelet chemokines in people with hypercholesterolemia: a randomized controlled study. Nutr Metab (London) . 2016; 13: 86.
draft
randomized, double blind, placebo -controlled study
Study goal
to evaluate the effects of a 24-week anthocyanine supplement on thrombocyte chemokines in people with hypercholesterolemia; Second, to investigate whether a reduction in the platelet chemokines causes changes in cholesterol or the inflammatory marker.
participant
One hundred and fifty people with hypercholesterolemia were recruited, with 75 participants accidentally assigned to the intervention group (31 men, 44 women) and 75 of the placebo group (32 men, 43 women). After 24 weeks, 146 participants ended the study (73 participants in each group). The study took place in China and it is assumed that all participants are Chinese descent. All participants were hypercholesterolemic with cholesterol levels of 200 to 310 mg/dl. The exclusion criteria included cardiovascular diseases in history, high blood pressure, diabetes mellitus, thyroid diseases, smoking or taking medication that could influence lipid parameters, inflammatory markers or chemokines. All participants were advised to continue their normal nutrition and to avoid food with high anthocyan content. At the beginning of the course there was no significant difference in any of the measured parameters between the 2 groups.
Intervention
The intervention consisted of 2 anthocyanin capsules (polyphenols AS, provided by Sandnes, Norway), which were taken twice a day (total dose of 320 mg anthocyanine per day) for 24 weeks. Placebo capsules were provided by the same manufacturer; The authors did not report on the content of the placebo.
target parameter
sober blood parameters for various platelets-chemokin concentrations were preserved at the beginning of the course, after 12 weeks and after 24 weeks. Lipid, highly sensitive C-reactive protein (HSCRP) and interleukin 1ß (IL-1ß) were also measured.
important knowledge
Overall, the anthocyanine supplementation led to favorable changes in the platelet chemokines compared to placebo as well as favorable changes in the lipids and inflammatory markers.
Bleeding chemokines
in week 12 only plasma-cxcl5 ( p = 0.021) and CXCL8 ( p = 0.015) were significantly reduced compared to placebo. In week 24 there was a significant acceptance of the average of the thrombocyte chemokines in the intervention vs. Placebo group: CXCL7 ( p = 0.001), CXCL5 ( p = 0.011), CXCL8 ( p = 0.004), CXCL 12 ( p = 0.023) and CCL2 ( p = 0.001). There was no statistically significant difference in the concentrations of CXCL41, CXCL1, macrophage migration inhibitor (MIF) or plasminogen-activator inhibitor 1 (PAI-1) between the two groups.
lipide
In week 24, the middle high-density lipoprotein cholesterol (HDL-C) increased significantly (1.22 mmol/l at the beginning of the study to 1.37 mmol/l; p = 0.018) and the mean low-density-lipoprotein cholesterol (LDL-C) sank significant (3.36 mmol/l to 3.01 mmol/l; p = 0.036) compared to the starting values in the intervention group. In the group comparison, there were also significant differences in the HDL-C ( p = 0.036) and LDL-C level ( p = 0.030) after 24 weeks.
inflammatory marker
Compared to the starting values, the anthocyanine supplementation in week 12 significantly reduced HSCRP and IL-1ß ( p <0.05). In week 24 IL-1ß, but not HSCRP, was statistically reduced compared to the starting value. However, the comparison with the placebo group led to significant decreases of the Plasma-HSCRP ( p = 0.001), IL-1ß ( p = 0.019) and SP-Selectin ( p = 0.027) in week 24.
correlations with lipids
In week 24, positive correlations were found between the CCL2 and CXCL7 mirrors and the LDL-C levels ( p = 0.001 for everyone). Finally, the CXCL8 levels correlated negatively with changes in the HDL-C in the intervention group ( p <0.001).
correlations with inflammatory markers
CXCL7 had positive correlations with HSCRP and IL-1ß ( p <0.001 for everyone), CCL2 was correlated positively with HSCRP ( p <0.001), CSCL12 significantly correlated with TNF-Alpha ( p <0.001), and there was a positive correlation between CXCL8 and SP-Selectin mirrors ( p <0.001).
In no of the two study groups were reported to unwanted interactions.
practice implications
Several studies have shown that anthocyanes protect against atherosclerosis. 1 more generally show evidence that the consumption of anthocyans with high cholesterol, obesity and/or inflammatory diseases can benefit. Reduce inflammatory markers and improve the endothelial function.
eat the rainbow of the natural colors "or" Your plate is like the palate of an artist that it should have a variety of colors "are simple ways to put the data into practice. anthocyane are a kind of flavonoid, and all flavonoids are phenolic compounds (ie polyphenols). Like many flavonoids, anthocyans give a variety of plants the characteristic color. Anthocyanin pigments usually range from blue to red, which explains why many fruits, vegetables and flowers with high anthocyanism appear violet. Some of these foods are eggplants, blueberries, blackberries, cherries, purple kohlrabi, violet leaves and beets. According to a review of anthocyanes in nature from 2017, there are at least "600 different naturally occurring anthocyans, which are widespread in at least 27 families, 73 genera and countless species".
It is possible to recommend an anthocyanine preparation patients, but the question would be: Why? In view of the abundance of blue/purple/red vegetable foods, every patient can certainly find anthocyan -rich foods that he likes. Of course, in addition to anthocyanes, thousands of other phytochemicals also contain full value food sources, which we still have to encapsulate in our reductionist pursuit of health. Many of these secondary plant substances are considered synergistic, which makes the consumption of entire plants even more attractive. In the current study, 320 mg of anthocyanes were only used for 24 weeks, with measurable benefits for cholesterol and inflammatory markers. If we recommend full value sources, how do we find out a daily dose of 320 mg? Is that a portion of blueberries or a bucket? A look at the database of the United States (USDA) database on the flavonoid content of food is revealing. 10 It contains data on 6 anthocyans: cyanidine, dolphinidine, malvidin, pelargonidine, peonidine and petunidine. The database uses a uniform 100 g portion for all anthocyan quantities, which makes comparisons relatively easy. If you look at ACAI berries, there are three categories: purple, fresh; Lila, frozen; And white, frozen. Fresh violet acai berries contain 53.64 mg anthocyan, frozen violet acai berries 61.94 mg and white 0.48 mg. This tells us that, as expected, anthocyane is the purple in violet acai berries and that freezing may somehow increase their concentration (possibly by reducing the water content). While Acai has become popular, berries that grow much closer to home can provide higher concentrations of anthocyans. Some examples (values are approximate) include blueberries, raw (160 mg); Cranberries, raw (100 mg); and blackberries, raw (100 mg). Other foods include concord grapes, raw (125 mg); Red wine, Syrah or Shiraz (140 mg), Radicchio, Roh (127 mg anthocyane per 100 g) and aubergine, raw (86 mg). An important indication is that cooking reduces the anthocyan concentration. Red cabbage is a good example of this. According to the USDA database, raw red cabbage contains 210 mg anthocyane per 100 gram portion. As soon as it is cooked, it has only 40 mg per 100 grams. Of course, 100 grams are a standardized amount that is used in the database and cannot be related to portions in a meal. In order to estimate this, a cup of blueberries weighs about 150 grams. In view of the high concentrations of anthocyans in different foods and the fact that the study showed a measurable benefit at 320 mg, there is no reason to pursue this precisely. The simplest means of ensuring that people consume enough anthocyanes is to promote the consumption of blue/purple/red foods for most meals and/or snacks. In this way, 320 mg should be easily reached per day. "Eat the rainbow of the natural colors" or "Your plate is like the palate of an artist that it should have a variety of colors" are simple ways to put the data into practice. My personal favorite way to describe which foods are rich in anthocyanes can be explained: “If it is blue, purple or red and appears in nature, it is probably rich in anthocyans. And the worse the given food is pushing a shirt, the higher the concentration.” Anthocyans are pigments, so it is inspiring for many to remember patients that the color and the nutrient are one and the same.
- Wallace TC. Anthocyans for cardiovascular diseases. Nutr . 2011; 2: 1-7.
- Afrin S, Gasparrini M, Forbes-Hernandez Ty, et al. Promising health benefits of strawberry: a focus on clinical studies. j agric foodchem . 2016; 64 (22): 4435-4449.
- Edirisinghe I, Burton-Freeman B. Anti-Diabetical effects of berry polyphenols-overview of proposed mechanisms of action. j berry res . 2016; 6 (2): 237-250.
- Luo T., Miranda-Garcia O., Adamson A., Sasaki G., Shay Nf. The development of obesity is reduced in high-fat mice, which were fed with entire raspberries, raspberry juice concentrate and a combination of the raspberry phytochemicals ellagic acid and raspberry keton. j berry res . 2016; 6 (2): 213-223.
- Alvarez-Suarez JM, Giampieri F, Tulipani S, et al. A one-month strawberry-rich anthocyanine supplement improves the cardiovascular risk, oxidative stress markers and platelet activation in humans. j nutr biochem . 2014; 25 (3): 289-294.
- Zhu Y, Huang X, Zhang y, et al. An anthocyanine supplementation improves the HDL-associated paraoxonase 1 activity and increases cholesterol-influx capacity in patients with hypercholesterolemia. j clin endocrinol metab . 2014; 99 (2): 561-569
- Zhu Y, Xia M, Yang Y, et al. Supplementation with cleaned anthocyanine improves the endothelial function via NO-CGMP activation in people with hypercholesterolemia. clinic chem . 2011; 57 (11): 1524-1533.
- y. ZHU, W. Ling, H. Guo et al. Anti -inflammatory effect of cleaned dietary anthocyanine in adults with hypercholesterolemia: a randomized controlled study. Nutr metab cardiovasc dis . 2013; 23 (9): 843-849
- Martín J., José Navas M., Jiménez-Moreno am, Asuero AG. Anthocyanin pigments: meaning, sample preparation and extraction. In: Soto-Hernandez, ed. phenolic compounds-natural sources, meaning and applications . Intech. https://www.intechopen.com/Books/phenolic-compounds-natural-sources-importance-and-applications/anthocyanin-pigments-importance-sample-PReparation-and-extraction . Published on March 15, 2017. Access on July 31, 2017.
- Bhagwat S, Haytowitz B. USDA database for the flavonoid content of selected food, version 3.1. US Agriculture Ministry, Agricultural Research Service. Home of the nutrient data laboratory: http://www.ars.usda.gov/nutrientdata/flav . Accessed on July 21, 2017.