Alternative to antibiotics - How do bacterial super bugs kill?

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Eine Forschungskooperation mit der Monash University hat eine aufregende Entdeckung gemacht, die schließlich zu gezielten Behandlungen zur Bekämpfung von arzneimittelresistenten bakteriellen Infektionen führen kann, einer der größten Bedrohungen für die globale Gesundheit. Eine aufregende Entdeckung, die schließlich zu gezielten Behandlungen zur Bekämpfung arzneimittelresistenter bakterieller Infektionen führen kann Die Studie, die von Associate Professor Fasséli Coulibaly vom Monash Biomedicine Discovery Institute und Professor Trevor Lithgow geleitet wird, ist in Nature Communications veröffentlicht. Es beschreibt die Verwendung hochauflösender Bildgebung, um herauszufinden, wie Viren, sogenannte Phagen, Salmonella Typhi, den Erreger von Typhus, angreifen und abtöten können, und um Wissenschaftlern ein neues Verständnis dafür …
Research cooperation with Monash University has made an exciting discovery that can ultimately lead to targeted treatments to combat bacterial infections, one of the greatest threats to global health. An exciting discovery, which ultimately lead to targeted treatments to combat pharmaceutical -resistant bacterial infections, can publish the study by Associate Professor Fasséli Coulibaly from Monash Biomedicine Discovery Institute and Professor Trevor Lithgow is published in Nature Communications. It describes the use of high -resolution imaging to find out how viruses, so -called phages, salmonella typhi, the pathogen of typhoid, can attack and kill, and a new understanding of this ... (Symbolbild/natur.wiki)

A research cooperation with Monash University has made an exciting discovery that can ultimately lead to targeted treatments to combat pharmaceutical -resistant bacterial infections, one of the greatest threats to global health.

an exciting discovery that can ultimately lead to targeted treatments to combat pharmaceutical -resistant bacterial infections

The study, which is led by Associate Professor Fasséli Coulibaly from Monash Biomedicine Discovery Institute and Professor Trevor Lithgow, is published in Nature Communications. It describes the use of high -resolution imaging to find out how viruses, so -called phages, Salmonella typhi, the pathogen of typhoid, can attack and kill, and to convey a new understanding of how they can be used in the ongoing fight against antibiotic resistance).

The study was a collaboration between researchers from the Monash Biomedicine Discovery Institute (BDI), Monash University Center to Impact Amr and the University of Cambridge.

incredible "choreography"

what they saw was an incredible “choreography” of the phages when they put together the main components of their particles: a head filled with viral DNA and a tail with which the bacteria were infected.

"We saw how the building blocks of the particle interlock in a complicated choreography. At the molecular level, the arms swing out and curl around each other to form a continuous chain that supports the head of the phage," said Associate Professor Coulibaly.

"This rigid chain shirt offers further protection for the DNA of the phages. Surprisingly, the tail remains flexible. It can bend and do not break if it captures the bacteria and finally injects the phage DNA."

phages are a class of viruses that infect bacteria

phages are a class of viruses that infect bacteria, and each phage is specific to the type of bacteria that it can kill. Phas can be cleaned up to a point where they are approved by the FDA for the treatment of people with bacterial infections. Documented successes were achieved in the USA, Europe and recently in Australia.

At Monash University, the Center to Impact AMR deals with these problems and examines the types of phages that are required for new "phageal therapies" for the treatment of bacterial infections.

"This finding will help us to overcome one of the most critical hurdles in phageal therapies, namely a precise understanding of the mode of action of phages in order to predict and select the best phages for every patient infection in advance," said Professor Lithgow.

"It could help to switch phageal therapies from a compassionate application in which all other treatment options are exhausted to a further widespread clinical application."

antimicrobial resistance (AMR) is one of the greatest threats to global health

antibiotic resistance (AMR) is one of the greatest threats to global health, nutritional security and economic development. It is an urgent health and humanitarian crisis in Asia that increases in severity worldwide.

AMR affects all aspects of society and is driven by many interconnected factors, including the excessive use of antibiotics and the rapid adaptability of bacteria to develop into forms of medicinal products. There are many risk groups for AMR infections, including COVID 19 patients with respiratory protection masks, mothers and children during birth, surgical patients, people with cancer and chronic diseases as well as older people.

The first authors of this study, Dr. Joshua Hardy and Dr. Rhys Dunstan, used the Ramaciotti Center for Kryo electron microscopy at Monash University, the Monash Molecular crystallization system and the Australian synchrotron for structural determination.