Resveratrol and the coronavirus
Resveratrol and the coronavirus
resveratrol and the coronavirus
by Prof. Gene Bruno, MS, MHS, RH (AHG) Huntington University of Health Sciences
in 2017, and in-vitro study1 examined the antiviral effect of resveratrol against cells of coronavirus infected patients. The results showed that resveratrol:
- clearly inhibited coronavirus infection
- clearly extended cellular survival after viral infection
- reduced replication of nucleokapside, a protein that is essential for replication of the coronavirus
- down -regulated apoptosis (ie cell death), which is induced by the coronavirus.
This study showed that resveratrol is a potent anti-coronavirus ingredient in-vitro , and the researchers suggested that resveratrol could be a potential antiviral against coronavirus in the near future. So what was the mechanism of action through which resveratrol against the coronavirus was effective? We don't know exactly, but we have an idea. Resveratrol can increase certain circulating immune cells known as Gamma Delta T cells.
Humanforschung2 was carried out to examine the effects of repeated doses of resveratrol (1,000 mg/day over 28 days) for circulating immune cells in healthy people. The results were that resveratrol was safe and well tolerated and with a significant increase in the number of circulating Gamma Delta-T cells (which act as the first line of defense and bridge between congenital and adaptive reactions) and were accompanied by regulatory T cells.
This becomes all the more important when you consider that analyzes of the T-Zell repertoire in healthcare workers who survived the Coronavirus infection during the outbreak of 2003 showed that their Gamma-Delta-T-Zell populations were selectively increased about three months after the disease has broken down. This was associated with a higher production of anti-coronavirus immunogloclobulin Giters. In addition, in-vitro Experiments showed that stimulated gamma-Delta-T cells have an interferongamma-dependent anti-coronavirus activity and are able to kill coronavirus infected target cells directly.
In summary, these results indicate that Gamma-Delta-T cells play a protective role during the coronavirus3-and resveratrol increases the number of circulating Gamma Delta T cells. Although there have yet been no clinical studies on people on the effects of resveratrol against the coronavirus, it seems advisable to take into account the use of this nutrotionalism because of its protective effect. A dose of 1,000 mg of resveratrol daily corresponds to the amount used in clinical human research, in which the Delta-T cells were effectively increased. references:1 Lin SC, Ho CT, Chuo Wh, Li S, Wang TT, Lin cc. Effective inhibition of MERS-COV infection by resveratrol. BMC Infect Dis. 2017 Feb 13; 17 (1): 144.
2 Espinoza JL, Trung LQ, Inaoka PT, Yamada K, An Dt, Mizuno S, NAKAO S, TAKAMI A. The repeated administration of resveratrol has measurable effects on circulating T cell sub-groups in humans. Oxid Med Cell Longev. 2017; 2017: 6781872.
3 Poccia F, Agrati C, Castilletti C, Bordi L, Gioia C, Horejsh D, Ippolito G, Chan PK, Hui DS, Sung JJ, Capobianchi Mr, Malkovsky M. Anti-Sales Acute Acute Syndrom Coronavirus immune reactions: The role that was played by V Gamma 9VV Delta 2 T cells. J infection. May 1, 2006; 193 (9): 1244-9.
Professor Gene Bruno, MS, MHS, The provost for Huntington College for Health Sciences, is a nutritionist, herbalist, author and educator. For more than 37 years, he has trained and trained natural product retailers and medical staff, researched and formulated natural products for dozens of food supplements and formulated articles on nutrition, herbal medicine, nutrotquional agents and integrative health issues for trade and consumers. It can be reached at gbruno@hchs.edu.
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