Life-changing advantages of an anti-adiposity medication in arthritis
Life-changing advantages of an anti-adiposity medication in arthritis
an Wonder remedy for weight reduction reduces significantly pain in the case of obese knee arthrosis and improves the ability of a person to carry out activities such as walking. This proves a clinical study that was carried out in 11 countries-the first of its kind that shows that one of of the new generation of anti-adiposity medication can also be used for the treatment of arthritis. The drug Semaglutid has achieved a reduction in pain that is comparable to that of opioid medication.
At the end of the study, many participants had learned so much pain relief that they could no longer be considered for the study, reports Henning Bliddal, a rheumatologist at the Copenhagen University Hospital in Bispebjerg and Frederiksberg, which was involved in the implementation of the study. "They received therapy that was so effective that they were more or less treated from the study," he explains.
The results are "important and could be helpful" for people with knee osteoarthritis, says Leigh Callahan, epidemiologist at the University of North Carolina in Chapel Hill.
The results were published today in the New England Journal of Medicine 1 . The study was sponsored and designed by Novo Nordisk, a company based in Bagsværd, Denmark. Novo Nordisk produces semaglutid her, which is sold as an Ozempic for the treatment of diabetes and as a Wegovy for the treatment of obesity . Bliddal worked for a short time as a paid consultant for the company during the study planning.
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Semaglutid also has anti -inflammatory effects that may contribute to pain relief.
Despite the advantages, Bliddal expresses concerns about the long -term perspective for those who use Semaglutid to relieve their knee arthrosis. "Do these people have to take Semaglutid forever" to manage their pain? People who set the medication usually increase the lost weight again , and the medication are expensive-a monthly price can cost hundreds of US dollars.
Callahan emphasizes that it is important to complement anti-adiposity medication with lifestyle changes in order to achieve long-term weight stabilization, even if the results appear "very exciting".
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Bliddal, H. et al. N. Engl. J. Med. 391, 1573–1583 (2024).