Imunk tijela 'liječene' rane s bakterijskim ribolovnim tkaninama
1 na miševima.
Studija pokazuje da je
Studija također naglašava novu obrambenu strategiju koja koristi imunološki sustav za zaštitu tijela izvan uništenja klica. Na naše iznenađenje "spriječiti sukobe neutrofila prije nego što uđete u ovaj biokemijski rat. Oni grade strukture kako bi se odvajali od ne-ja samog sebe i održavali patogene", kaže koautor studije, Andrés Hidalgo, imunolog na Yale School of Medicins u New Havenu, Connecticut.
Multitalizirane imunološke stanice
Neutrofili su poznati po trovanju prodiranim mikrobima i proždiru ih. Ali ove strategije uzrokuju "kolateralnu štetu" u tijelu ubijanjem zdravih stanica na tom području, objašnjava Hidalgo.
kako bi ispitali imaju li neutrofili još jedan trik u rukavima, istraživači su pregledali uzorke miša, pluća i crijeva - organe koji su u kontaktu s vanjskim svijetom i obloženi su zaštitnim slojevima kako bi oduzeli patogene i strane tvari. Hidalgo i njegovi kolege otkrili su da visok postotak neutrofila proizvodi kolagen i druge proteine u tim tkivima koji su važni za formiranje 'izvanstanična matrica skela su koja okružuje i daje strukturu tkiva. Suprotno tome, neutrofili nisu dali nikakav kolagen u krvi.
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vicanolo, T. i sur. Nature https://doi.org/10.1038/s41586-025-08741-5 (2025).
članak
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