Immunk bodies ‘treated’ wounds with bacterial fishing fabrics
Immunk bodies ‘treated’ wounds with bacterial fishing fabrics
Immune cells in the skin 'Cauterize' open wounds and create 'pavement' to prevent the spread of harmful bacteria and foreign molecules from injury points, a study 1 on mice.
The study shows that White blood cells, which are known as neutrophils , sticky, protein-rich rings are formed by places where the skin was injured. These rings capture pathogenic and make sure that they do not penetrate deeper tissue.
Scientists have long known that neutrophils lead chemical warfare by releasing toxins to kill penetrating microorganisms. But the new work that was published in Nature today shows "an additional role for neutrophils that we had not recognized," says Niki Moutsopoulos, clinical immunologist at the National Institutes of Health (NIH) in Bethesda, Maryland, which was not involved in the study. The results show that neutrophils help with wound healing - and are not just immunological warriors, she adds.
The study also emphasizes a new defense strategy that uses the immune system to protect the body beyond the destruction of germs. To our surprise "Prevent neutrophil conflicts before you enter this biochemical war. They build structures to separate themselves from non-self-self and keep pathogenic," says co-author of the study, Andrés Hidalgo, immunologist at the Yale School of Medicine in New Haven, Connecticut.
multitalized immune cells
neutrophils are known for poisoning penetrating microbes and devouring them. But these strategies cause “colateral damage” in the body by killing healthy cells in the area, explains Hidalgo.
In order to examine whether neutrophils have another trick in their sleeves, the researchers examined samples of mouse, lungs and intestines - organs that are in contact with the outside world and are lined with protective layers to ward off pathogens and foreign substances. Hidalgo and his colleagues found that a high percentage of neutrophils produces collagen and other proteins in these tissues that are important for the formation of the ’Extracellular Matrix’ are a scaffold that surrounds and gives tissue structure. In contrast, neutrophils did not give any collagen in the blood.
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Vicanolo, T. et al. Nature https://doi.org/10.1038/s41586-025-08741-5 (2025).