Bergamot for hypercholesterolemia: patient compliance made easy

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Bergamotte für Hypercholesterinämie: Patienten-Compliance leicht gemacht Von Prof. Gene Bruno, MS, MHS, RH(AHG) Huntington College of Health Sciences Wenn es um nutrazeutische Entscheidungen zur Behandlung von Hypercholesterinämie geht, scheint der Himmel die Grenze zu sein. Allerdings sind viele der Nutrazeutika mit Problemen behaftet, wie z. B. einer begrenzten Wirksamkeit und der Notwendigkeit relativ großer Dosen, die zwei- oder dreimal täglich eingenommen werden müssen. Als medizinisches Fachpersonal wissen Sie, dass letzteres Problem die Patienten-Compliance beeinträchtigen kann. Deshalb halte ich Bergamotte – und einen bestimmten Stoff namens Bergavit 40 – für eine so interessante Option zur Behandlung von Hypercholesterinämie. Bergamotte ist der …
Bergamot for hypercholesterolemia: Patient compliance made easy by Prof. Gene Bruno, MS, MHS, RH (AHG) Huntington College of Health Sciences When it comes to the treatment of hypercholesterolaemia, the sky seems to be the border. However, many of the nutrotquipment are affected with problems, such as: B. a limited effectiveness and the necessity of relatively large doses that have to be taken two or three times a day. As a medical specialist, you know that the latter problem can affect patient compliance. That's why I consider Bergamot - and a certain fabric called Bergavit 40 - to be such an interesting option for the treatment of hypercholesterolemia. Bergamot is ... (Symbolbild/natur.wiki)

Bergamot for hypercholesterolemia: Patient compliance made easy

by Prof. Gene Bruno, MS, MHS, RH (AHG) Huntington College of Health Sciences

When it comes to nutritional decisions to treat hypercholesterolemia, the sky seems to be the border. However, many of the nutrotquipment are affected with problems, such as: B. a limited effectiveness and the necessity of relatively large doses that have to be taken two or three times a day. As a medical specialist, you know that the latter problem can affect patient compliance. That's why I consider Bergamot - and a certain fabric called Bergavit 40 - to be such an interesting option for the treatment of hypercholesterolemia.

Bergamotte is the common name of the fruit citrus bergamia risso (Raubete family family), which differs from other citrus fruits by the composition and content of various flavonoids such as neoeriocitrin, neohespperidine and naringin. Preclinical and clinical studies showed a hypocholesterine -temical property of c. Bergamia flavonoids. In the clinical studies on Bergamot extracts, however, doses of between 1,000 and 1,500 mg per day were used, which sometimes required a daily dosage scheme. 1,2

A newer, six-month Bergamot study3 was published in the magazine borders in pharmacology in 2016. In this study, a specific bergamot extract called Bergavit 40 was used, which was standardized to provide 150 mg of the Flavonoid Neoeriocitrin, Neohesperidin and Naringin in a dose of 400 mg-this is the daily dose that was used in the study of 80 subjects (42 men and 30 women): 55 ± 13 years). All subjects had moderate hypercholesterolemia (e.g. Plasma-LDL-C concentrations between 160 and 190 mg/dl).

At the start of the study and after six months of taking Bergavit 40, total cholesterol (TC), triglycerides (TG) and high density lipoprotein cholesterol (HDL-C) were measured by routine laboratory methods, while LDL-C was calculated. In addition, a color dopper ultrasound of the carotid arteries was carried out at the start of the course and after 6 months.

The results showed that the plasmalipides significantly improved with a 12- and 20 percent decrease in TC, LDL-C (p <0.0001 for both) or a 17 percent decrease in TG (p = 0.0020), while HDL-C increase 8 %. (P = 0.0007). A stronger reduction in the Plasma-LDL-C level was achieved in subjects with higher LDL-C output values ​​(p = 0.004). In addition, the carotid ultrasound showed that the carotid-intima-media thickness (IMT) decreased as a marker for subclinical atherosclerosis after six-month supplementation with Bergavit 40 from 1.2 ± 0.4 to 0.9 ± 0.1 mm (25 percent; p <0.0001).

In view of the positive results of these studies and the dose of 400 mg/day, I suggest that Bergavit 40 is a worthwhile nutrotquake that you should consider for your hypercholesterineemic patients, especially for those for whom compliance could be a problem.

references:
1 Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. third edition New York, NY: Oxford University Press; 1999. 2 Krinsky Ni, Landrum Jt, Bone Ra. Biological mechanisms of the protective function of Lutein and Zeaxanthin in the eye. annual Rev. Nutr. 2003; 23: 171-201. 3 Vishwanathan R, Kuchan MJ, Johnson ej. Lutein is the prevailing carotenoid in the child's brain. Poster No. 1.23. 16. International symposium about carotenoids. Acta Biologica Cracoviensia series Botanica.2011; 53 (Suppl.1): 29. 4 Johnson EJ et al., Lutein and Zeaxanteenspiegel in the brain are related to the cognitive function in a hundred-year-old (summary) fueb j. 2011; 25: 975. 5 Lindbergh Ca, Mewborn cm, Hammond BR, Renzi-Hammond LM, Curran-Celentano JM, Miller LS. 6 Relationship between Lutein and ZeaxanteLhlichen to neurocognitive functions: an FMRI study of older adults. j inte neuropsychol Soc. 2016 Oct 25: 1-12. [Epub Ahead of Print]. 7 Vishwanathan R, Iannaccone A, Scott TM, Kritchevsky SB, Jennings BJ, Carboni G, Forma G, Satterfield S, Harris T, Johnson KC, Schalch W, Renzi LM, Rosano C, Johnson EJ. The optical density of the maculara pigment is related to the cognitive function in older people. old aging. March 2014; 43 (2): 271-5.

Professor Gene Bruno, MS, MHS, The Provost for Huntington College for Health Sciences, is a nutritionist, herbalist, writer and educator. For more than 37 years, he has been forming and trained in natural product dealers and medical specialists, has researched and formulated natural products for dozens of food supplements and has written articles and integrative health issues for trade and consumers publications and peer reviewed publications. It can be reached at gbruno@hchs.edu.

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